Mycobacterium bovis

Summary

  • Scientific NameMycobacterium bovis
  • Rankspecies
  • Taxonomy ID1765
  • speciesMycobacterium bovis
  • genusMycobacterium
  • orderActinomycetales
  • classActinobacteria
  • phylumActinobacteria

Mycobacterium tuberculosis insilico spoligotype

ST No. Lineage Spoligotype Description Octal
1044 BOVIS1 676773777767600

备注

病原菌名称 危害程度分类 实验活动所需生物安全实验室级别 运输包装分类 备注
学名 中文名 大量活菌操作 动物感染实验 样本检测 非感染性材料的实验 A/B UN 编号
Mycobacterium bovis 牛型分枝杆菌 第二类 BSL-3 ABSL-3 BSL-2 BSL-1 A UN 2814

Drug resistance prediction

Protein Resistance Variant/Evidance alignment
KATG INH 463: R => L

Antibiotic resistance factors

type gene identity% query hit genome alignment
Enzyme RbpA 89.5% NODE_44_length_29632_cov_35.283_ID_87 HQ203032
Enzyme Rv3361c 100.0% NODE_10_length_123218_cov_35.4808_ID_19 AL123456
Enzyme aac 100.0% NODE_49_length_26863_cov_37.4839_ID_97 AL123456
Enzyme erm(37) 58.9% NODE_37_length_42096_cov_36.0382_ID_73 AL123456
Enzyme tsnR 99.6% NODE_19_length_74344_cov_36.0489_ID_37 AL123456
VAR embA 100.0% NODE_30_length_51759_cov_38.8289_ID_59 AL123456
VAR embB 7.8% NODE_30_length_51759_cov_38.8289_ID_59 AY198120
VAR embC 99.9% NODE_30_length_51759_cov_38.8289_ID_59 AL123456
VAR folP-2 98.9% NODE_29_length_55419_cov_36.8134_ID_57 AE000516
VAR folP2 86.2% NODE_11_length_122310_cov_36.2959_ID_21 AL123456
VAR glbN 100.0% NODE_8_length_131149_cov_34.5585_ID_15 AL123456
VAR gyrA 100.0% NODE_3_length_186737_cov_37.7369_ID_5 AE000516
VAR parE1 100.0% NODE_37_length_42096_cov_36.0382_ID_73 AL123456
VAR parE2 100.0% NODE_42_length_36483_cov_32.6309_ID_83 AL123456
VAR rpoB 100.0% NODE_5_length_161545_cov_36.3124_ID_9 AL123456

Virulence factors

class factor gene gap identity% score alignment
Amino acid and purine metabolism Glutamine synthesis glnA1 0 99.8% 2547.0
Amino acid and purine metabolism Leucine synthesis leuD 0 100.0% 1029.0
Amino acid and purine metabolism Lysine synthesis lysA 0 99.8% 2278.0
Amino acid and purine metabolism Proline synthesis proC 0 100.0% 1417.0
Amino acid and purine metabolism Purine synthesis purC 0 100.0% 1554.0
Amino acid and purine metabolism Tryptophan synthesis trpD 92 73.5% 1280.0
Anaerobic respiration Fused nitrate reductase narX 0 99.8% 3447.0
Anaerobic respiration Nitrate reductase narG 0 99.9% 6608.0
Anaerobic respiration Nitrate reductase narH 0 100.0% 3012.0
Anaerobic respiration Nitrate reductase narI 0 99.6% 1299.0
Anaerobic respiration Nitrate reductase narJ 0 100.0% 1118.0
Anaerobic respiration Nitrate_nitrite transporter narK2 0 100.0% 2002.0
Anti-apoptosis factor NuoG nuoG 15 98.1% 4089.0
Catabolism of cholesterol Cyp125 cyp125 0 99.8% 2214.0
Catabolism of cholesterol FadE28 fadE28 0 100.0% 1727.0
Catabolism of cholesterol FadE29 fadE29 0 100.0% 2038.0
Cell surface components Carboxylesterase caeA 11 97.9% 2679.0
Cell surface components Exported repetitive protein erp 0 99.6% 1453.0
Cell surface components GPL locus fad23 0 100.0% 3005.0
Cell surface components GPL locus fadE5 0 99.8% 3116.0
Cell surface components GPL locus fmt 0 99.6% 1362.0
Cell surface components GPL locus gap 0 100.0% 1237.0
Cell surface components GPL locus gtf1 0 100.0% 2197.0
Cell surface components GPL locus gtf2 0 100.0% 2127.0
Cell surface components GPL locus gtf3 116 69.6% 1475.0
Cell surface components GPL locus mbtH 5 71.1% 321.0
Cell surface components GPL locus mmpL10 0 99.9% 4987.0
Cell surface components GPL locus mmpL4a 0 99.9% 4904.0
Cell surface components GPL locus mmpL4b 44 66.0% 3452.5
Cell surface components GPL locus mmpS4 0 100.0% 726.0
Cell surface components GPL locus mps1 0 100.0% 12903.0
Cell surface components GPL locus papA3 0 100.0% 2487.0
Cell surface components GPL locus pe 4 98.9% 1926.0
Cell surface components GPL locus pks 0 99.6% 10728.0
Cell surface components GPL locus rmlA 0 100.0% 1486.0
Cell surface components GPL locus rmlB 5 76.9% 1390.0
Cell surface components Heparin-binding hemagglutinin hbhA 0 100.0% 950.0
Cell surface components Lipoprotein lprG 0 100.0% 1224.0
Cell surface components Methyltransferase mmaA4 0 99.7% 1577.0
Cell surface components Mycolic acid trans-cyclopropane synthetase cmaA2 0 100.0% 1614.0
Cell surface components MymA operon adhD 0 100.0% 1935.0
Cell surface components MymA operon chp 0 100.0% 2517.0
Cell surface components MymA operon fadD13 0 100.0% 2580.0
Cell surface components MymA operon lipR 0 100.0% 1587.0
Cell surface components MymA operon mymA 0 100.0% 2650.0
Cell surface components MymA operon sadH 0 100.0% 1378.0
Cell surface components MymA operon tgs4 0 100.0% 2421.0
Cell surface components MymA operon x 10 96.3% 1377.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport ddrA 0 100.0% 1653.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport ddrB 0 100.0% 1466.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport drrC 0 100.0% 1372.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport fadD22 0 100.0% 3621.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport fadD26 0 100.0% 2990.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport fadD28 40 93.5% 3004.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport fadD29 0 100.0% 3161.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport lppx 0 100.0% 1175.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport mas 0 100.0% 10850.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport mmpL7 13 98.6% 4563.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport papA5 0 100.0% 2188.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport pks1 485 76.9% 8160.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport pks15 1624 23.2% 2514.5
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport pks15_1 7 99.7% 10667.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport ppsA 121 88.4% 4916.5
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport ppsB 1 99.9% 7886.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport ppsD 0 100.0% 9384.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport ppsE 0 99.9% 7695.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport tesA 0 100.0% 1396.0
Cell surface components PDIM (phthiocerol dimycocerosate) and PGL (phenolic glycolipid) biosynthesis and transport x 0 100.0% 2139.0
Cell surface components Potassium_proton antiporter kefB 0 99.7% 1851.0
Cell surface components Proximal cyclopropane synthase of alpha mycolates pcaA 0 100.0% 1524.0
Cell surface components Sulfolipid-1 biosynthesis and transport mmpL8 0 100.0% 5410.0
Cell surface components Sulfolipid-1 biosynthesis and transport papA1 41 92.0% 2454.0
Cell surface components Sulfolipid-1 biosynthesis and transport papA2 4 98.8% 2134.0
Cell surface components Sulfolipid-1 biosynthesis and transport pks2 881 57.9% 6279.0
Cell surface components Sulfolipid-1 biosynthesis and transport stf0 0 100.0% 1425.0
Cell surface components Trehalose-recycling ABC transporter chp1 5 98.3% 1443.0
Cell surface components Trehalose-recycling ABC transporter fad23 0 100.0% 3004.0
Cell surface components Trehalose-recycling ABC transporter icl2 0 100.0% 3964.0
Cell surface components Trehalose-recycling ABC transporter lpqY 0 100.0% 2386.0
Cell surface components Trehalose-recycling ABC transporter sap 28 89.4% 1171.0
Cell surface components Trehalose-recycling ABC transporter sugA 19 93.8% 1456.0
Cell surface components Trehalose-recycling ABC transporter sugB 5 98.2% 1355.0
Cell surface components Trehalose-recycling ABC transporter sugC 0 100.0% 1973.0
Lipid and fatty acid metabolism FAS-II kasB 21 95.2% 2134.0
Lipid and fatty acid metabolism Isocitrate lyase icl 0 100.0% 2223.0
Lipid and fatty acid metabolism Lipase lipF 0 100.0% 1695.0
Lipid and fatty acid metabolism Lipid phosphatase sapM 0 100.0% 1568.0
Lipid and fatty acid metabolism Pantothenate synthesis panC 0 100.0% 1553.0
Lipid and fatty acid metabolism Pantothenate synthesis panD 0 100.0% 712.0
Lipid and fatty acid metabolism Phospholipases C plcA 31 68.4% 1982.0
Lipid and fatty acid metabolism Phospholipases C plcB 131 54.0% 1527.0
Lipid and fatty acid metabolism Phospholipases C plcC 12 68.1% 1920.0
Lipid and fatty acid metabolism Phospholipases C plcD 171 66.7% 1840.0
Mammalian cell entry (mce) operons Mce1 mce1A 0 100.0% 2321.0
Mammalian cell entry (mce) operons Mce1 mce1B 0 100.0% 1756.0
Mammalian cell entry (mce) operons Mce1 mce1C 0 100.0% 2734.0
Mammalian cell entry (mce) operons Mce1 mce1D 0 99.8% 2753.0
Mammalian cell entry (mce) operons Mce1 mce1E 0 100.0% 1985.0
Mammalian cell entry (mce) operons Mce1 mce1F 0 99.8% 2678.0
Mammalian cell entry (mce) operons Mce2 mce2A 0 99.8% 2078.0
Mammalian cell entry (mce) operons Mce2 mce2B 0 100.0% 1743.0
Mammalian cell entry (mce) operons Mce2 mce2C 0 100.0% 2511.0
Mammalian cell entry (mce) operons Mce2 mce2D 0 100.0% 2644.0
Mammalian cell entry (mce) operons Mce2 mce2E 18 95.5% 1924.0
Mammalian cell entry (mce) operons Mce2 mce2F 0 100.0% 2680.0
Mammalian cell entry (mce) operons Mce4 mce4A 0 100.0% 2020.0
Mammalian cell entry (mce) operons Mce4 mce4B 0 100.0% 1746.0
Mammalian cell entry (mce) operons Mce4 mce4C 0 99.7% 1790.0
Mammalian cell entry (mce) operons Mce4 mce4D 0 100.0% 2302.0
Mammalian cell entry (mce) operons Mce4 mce4E 0 100.0% 1941.0
Mammalian cell entry (mce) operons Mce4 mce4F 0 100.0% 2999.0
Metal exporters Copper exporter ctpV 0 100.0% 3932.0
Metal exporters P(1)-type Mn2+ transporting ATPase ctpC 0 100.0% 3554.0
Metal uptake ABC transporter irtA 0 100.0% 4371.0
Metal uptake ABC transporter irtB 0 100.0% 2877.0
Metal uptake Heme uptake mmpL11 1 99.9% 4897.0
Metal uptake Heme uptake mmpL3 0 99.9% 4777.0
Metal uptake Heme uptake x 0 100.0% 666.0
Metal uptake Iron-dependent regulator ideR 0 100.0% 1174.0
Metal uptake Magnesium transport mgtC 0 100.0% 1188.0
Metal uptake Mycobactin fadD33 0 100.0% 2664.0
Metal uptake Mycobactin fadE14 0 100.0% 1961.0
Metal uptake Mycobactin mbtA 0 100.0% 2956.0
Metal uptake Mycobactin mbtB 0 99.9% 7277.0
Metal uptake Mycobactin mbtC 0 100.0% 2312.0
Metal uptake Mycobactin mbtD 0 100.0% 5109.0
Metal uptake Mycobactin mbtE 0 99.9% 8952.0
Metal uptake Mycobactin mbtF 0 100.0% 7458.0
Metal uptake Mycobactin mbtG 0 100.0% 2246.0
Metal uptake Mycobactin mbtH 0 98.6% 386.0
Metal uptake Mycobactin mbtI 0 99.8% 2250.0
Metal uptake Mycobactin mbtJ 0 100.0% 1785.0
Metal uptake Mycobactin mbtK 0 100.0% 1139.0
Metal uptake Mycobactin x 0 100.0% 404.0
Phagosome arresting Nucleoside diphosphate kinase ndk 4 97.1% 672.0
Phagosome arresting PE family protein PE_PGRS30 352 36.8% 1004.0
Phagosome arresting Tyrosine phosphatase ptpA 19 88.3% 756.0
Proteases Proteasome-associated proteins mpa 0 100.0% 3073.0
Proteases Proteasome-associated proteins pafA 5 98.9% 2310.0
Proteases Zn++ metallophrotease zmp1 0 99.8% 3512.0
Regulation (p)ppGpp synthesis and hydrolysis relA 0 99.9% 4025.0
Regulation DevR_S devR_dosR 108 50.2% 531.0
Regulation DevR_S devS 0 100.0% 2875.0
Regulation MosR mosR 0 100.0% 1117.0
Regulation MprA_B mprA 2 99.1% 1141.0
Regulation MprA_B mprB 0 100.0% 2502.0
Regulation PhoP_R phoP 0 99.6% 1131.0
Regulation PhoP_R phoR 92 73.9% 1295.0
Regulation PrrA_B prrA 0 100.0% 1162.0
Regulation PrrA_B prrB 23 95.1% 2219.0
Regulation RegX3 espE 0 100.0% 2193.0
Regulation RegX3 espF 0 100.0% 515.0
Regulation RegX3 espG1 0 100.0% 1458.0
Regulation RegX3 espH 0 100.0% 929.0
Regulation RegX3 regX3 0 100.0% 1138.0
Regulation SenX3 senX3 0 99.8% 2018.0
Regulation Sigma A sigA_rpoV 0 99.8% 2644.0
Regulation Sigma D sigD 21 90.1% 944.0
Regulation Sigma E sigE 47 81.7% 1113.0
Regulation Sigma F sigF 21 92.0% 1199.0
Regulation Sigma H sigH 7 97.3% 1263.0
Regulation Sigma L sigL 0 99.4% 879.0
Regulation Sigma M sigM 0 100.0% 1000.0
Regulation WhiB3 whiB3 0 100.0% 561.0
Secreted proteins 19-kD protein lpqH 0 99.4% 798.0
Secreted proteins Alpha-crystallin hspX 0 100.0% 736.0
Secreted proteins Antigen 85 complex fbpA 0 100.0% 1813.0
Secreted proteins Antigen 85 complex fbpB 0 100.0% 736.0
Secreted proteins Antigen 85 complex fbpC 0 100.0% 1840.0
Secreted proteins Enhanced intracellular survival protein eis 0 100.0% 3863.0
Secreted proteins Protein kinase G pknG 0 100.0% 3863.0
Secretion system Accessory secretion factor secA2 0 99.9% 3950.0
Secretion system ESX-1 (T7SS) eccA1 0 100.0% 2879.0
Secretion system ESX-1 (T7SS) eccB1 0 100.0% 2473.0
Secretion system ESX-1 (T7SS) eccCa1 0 100.0% 3874.0
Secretion system ESX-1 (T7SS) eccCb1 0 100.0% 2574.0
Secretion system ESX-1 (T7SS) eccE1 0 100.0% 2427.0
Secretion system ESX-1 (T7SS) espA 0 100.0% 1968.0
Secretion system ESX-1 (T7SS) espB 0 100.0% 2383.0
Secretion system ESX-1 (T7SS) espC 0 100.0% 523.0
Secretion system ESX-1 (T7SS) espD 0 100.0% 991.0
Secretion system ESX-1 (T7SS) espI 2 99.3% 2090.0
Secretion system ESX-1 (T7SS) espL 2 98.3% 560.0
Secretion system ESX-1 (T7SS) espR 0 100.0% 676.0
Secretion system ESX-1 (T7SS) mycP1 0 100.0% 2370.0
Secretion system ESX-2 (T7SS) PE36 0 100.0% 377.0
Secretion system ESX-2 (T7SS) PPE69 0 100.0% 2036.0
Secretion system ESX-2 (T7SS) eccA2 0 100.0% 3128.0
Secretion system ESX-2 (T7SS) eccB2 0 100.0% 2523.0
Secretion system ESX-2 (T7SS) eccC2 0 100.0% 4322.0
Secretion system ESX-2 (T7SS) eccD2 40 92.1% 2359.0
Secretion system ESX-2 (T7SS) eccE2 0 99.8% 2748.0
Secretion system ESX-2 (T7SS) espG2 0 100.0% 1398.0
Secretion system ESX-2 (T7SS) esxD 0 99.1% 532.0
Secretion system ESX-2 (T7SS) mycP2 0 100.0% 2896.0
Secretion system ESX-2 (T7SS) x 27 89.1% 1107.0
Secretion system ESX-3 (T7SS) PE5 0 100.0% 488.0
Secretion system ESX-3 (T7SS) PPE4 0 100.0% 2668.0
Secretion system ESX-3 (T7SS) eccA3 0 100.0% 3182.0
Secretion system ESX-3 (T7SS) eccB3 0 100.0% 2780.0
Secretion system ESX-3 (T7SS) eccC3 432 67.5% 4605.0
Secretion system ESX-3 (T7SS) eccD3 0 100.0% 2292.0
Secretion system ESX-3 (T7SS) eccE3 0 100.0% 1720.0
Secretion system ESX-3 (T7SS) espG3 0 100.0% 1531.0
Secretion system ESX-3 (T7SS) esxG 0 100.0% 468.0
Secretion system ESX-3 (T7SS) esxH 0 100.0% 506.0
Secretion system ESX-3 (T7SS) mycP3 0 100.0% 2372.0
Secretion system ESX-4 (T7SS) cccD4 0 100.0% 2300.0
Secretion system ESX-4 (T7SS) eccB4 364 22.6% 550.0
Secretion system ESX-4 (T7SS) eccC4 0 100.0% 6337.0
Secretion system ESX-4 (T7SS) esxT 0 100.0% 514.0
Secretion system ESX-4 (T7SS) esxU 0 100.0% 736.0
Secretion system ESX-4 (T7SS) mycP4 0 100.0% 2318.0
Secretion system ESX-4 (T7SS) x 0 99.8% 1996.0
Secretion system ESX-5 (T7SS) PE18 0 100.0% 470.0
Secretion system ESX-5 (T7SS) PE19 0 100.0% 472.0
Secretion system ESX-5 (T7SS) PPE25 0 100.0% 1985.0
Secretion system ESX-5 (T7SS) PPE26 0 100.0% 1985.0
Secretion system ESX-5 (T7SS) PPE41 0 100.0% 1018.0
Secretion system ESX-5 (T7SS) cyp143 0 100.0% 2048.0
Secretion system ESX-5 (T7SS) eccA5 0 100.0% 3098.0
Secretion system ESX-5 (T7SS) eccB5 43 91.5% 2385.0
Secretion system ESX-5 (T7SS) eccCa5 956 31.3% 2301.0
Secretion system ESX-5 (T7SS) eccCb5 0 100.0% 7251.0
Secretion system ESX-5 (T7SS) eccD5 0 100.0% 2508.0
Secretion system ESX-5 (T7SS) eccE5 0 100.0% 2127.0
Secretion system ESX-5 (T7SS) esxM 0 100.0% 503.0
Secretion system ESX-5 (T7SS) esxN 0 100.0% 485.0
Secretion system ESX-5 (T7SS) mycP5 0 100.0% 3088.0
Secretion system ESX-5 (T7SS) x 0 100.0% 1535.0
Stress adaptation AhpC ahpC 0 100.0% 1024.0
Stress adaptation Catalase-peroxidase katG 22 97.0% 3842.0
Stress adaptation Cu,Zn superoxide dismutase sodC 0 100.0% 1261.0
Stress adaptation Iron-cofactored SOD sodA 0 99.5% 1113.0
Stress adaptation Pore-forming protein ompA 6 98.2% 1625.0

Assembly statistics

Assembly seq
# contigs (>= 0 bp) 1037
# contigs (>= 1000 bp) 95
Total length (>= 0 bp) 4419437
Total length (>= 1000 bp) 4258775
# contigs 115
Largest contig 264831
Total length 4273495
GC (%) 65.56
N50 106160
N75 51759
L50 14
L75 30
# N's per 100 kbp 2.29

Syntenic comparison

Genome Coverage 99.74%
Average Nucleotide Identity(ANI) 99.94%

Genome & Accessory Genome

Genome Sequences and Annotations (Genebank format) 4.42Mbp

Genome phylogeny based on gene content

Whole Genome Sequences Phylogenetic Tree